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Buy metformin 850 mg daily and 50 of folic acid daily. The patients were followed for 7 years after stopping the diet." On January 31, 2013, a research group in Korea found that, by lowering the ratio of folate to vitamin B12, the folic acid caused a lower than normal conversion of folate to vitamin B12 in humans. The study, "Influence of Vitamins B12 and Folate on Serum Tissue Levels of Homocysteine in Adults with Low Levels," published in the Lancet, concluded that, "A large dose of folic acid in the absence of vitamin B12 caused serum homocysteine levels to decline." Other evidence of the effects vitamin B12 In 2012, researchers at the University of California San Francisco (UCSF) looked at the effects of folic acid on the development of colon cancer, saying in a study that, The use of folic acid is often recommended to promote the prevention of colorectal cancer but is not known to prevent malignancy. The authors conclude that a reduction in colon cancer risk is not likely to result from use of folic acid, but it remains unclear whether the use of folic acid is associated with a reduction in malignancy risk or both." 1 A study of more than 1475 adults, "Folic Acid Supplementation and Prostate Cancer Survival: a Population‐Based Meta‐Analysis of Randomized Controlled Trials," published in April 2012 PLOS ONE, concluded that, "…given the known risks versus benefits, it would be unconscionable not to recommend folic acid supplementation for men. But because of the high cost supplementation, only modest, targeted folic acid supplements for men would be sensible. women, the benefit is somewhat clearer but the harms of taking extra folic acid appear modest enough not to justify additional folic acid supplementation in women. Although it may be prudent to advise women keep their overall folic acid absorption low by supplementing with a single supplement containing 400 µg folic acid, the benefits of maintaining adequate homocysteine levels and avoiding a vitamin B12 deficiency outweigh these risks." 1 A 2010 study found an Metformin 500mg $34.88 - $0.39 Per pill 8 percent reduction in colon cancer risk associated with folic acid supplementation in over 7,000 women Israel. However, the study researchers warned, …the effect is modest and may not result in a significant reduction cancer incidence in the population to which intervention is applied. Another study, published in July 2010 Cancer Prevention Research, a journal of the American Association for Cancer Research, found that, "…men receiving the highest levels of folic acid had 2.24-fold and 3.24-fold lower risk of having colonic, endometrial and rectal cancers, respectively, than women receiving the lowest blood levels (≤500µg folic acid/day." 2 Folic acid supplements also increase risk of depression in women. From 2008 to 2009, 1.2 million women and 442,000 men in the U.S. took a vitamin B12 supplement. After the research was published, FDA reported that the study found no link between depression and taking a folic acid supplement. Folic acid supplementation is not needed to develop neural tube defects In 2010, a large prospective study was published in The Lancet looking at relationship between folate deficiency and neural tube defects. The researchers concluded, The risk of neural tube defects was not decreased by taking a diet rich in folic acid." 3 Folic acid supplementation does not cause brain damage Even if it was proven that folic acid caused brain damage, it would prove insufficient evidence of causation. It would be important to determine exactly which brain systems are affected to prove causality. In July 2009, the New England Journal of Medicine reported that, "Despite a long history of use, the medical consensus currently lacks evidence that folate supplements or fortified food can prevent stroke, dementia, or other cognitive behavioral problems. It is reasonable to conclude that dietary supplements contain small amounts of folic acid do not protect against adverse cardiovascular events or cancers, such as leukemia, colorectal cancer, or lung cancer. Many questions remain about the health effects of folic acid: why is it so poorly absorbed? Why is it more toxic at the cellular level than tissue, and how is it able to affect various brain functions without damaging the other tissue around it? If it was possible to prove a causal relationship between folic acid supplementation and a number of harmful outcomes, wouldn't the medical community demand such evidence? If folate was proven to cause brain damage or even cancer, wouldn't the medical community demand such evidence? Or would it be easier for them to believe the media hype and propaganda about the benefits of folate? As a result, we cannot ignore the numerous.

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